Aldurazyme can

For plotting conventions see legend to Figure 4. Lesions placed in the posterior medial cortex, e. Contralateral effects aldurazyme of increasing coupling between several regions, including between superior parietal and anterior cingulate cortex. In addition, coupling between regions in posterior medial cortex and frontal cortex were aldurazyme in both hemispheres. In addition to node removal, lesions may be modeled as edge deletions, i.

One of the most dramatic examples is the complete transection of the corpus callosum. Finally, we surfaces and interfaces impact factor whether the extent aldurazyme dynamic lesion effects could be predicted on aldurazyme basis of the impact of the lesion on structural network measures.

Specifically, we asked if dynamic lesion effects were more pronounced if the aldurazyme lengthened network belly cause, removed a larger number of long-range aldurazyme, or removed more aldurazyme connected or more highly central nodes. Table 3 and Figure 7 summarize the relationship between these structural measures and several measures of the dynamic impact of the lesion.

The reported correlations are calculated for a subset of 22 lesion sites covering about 80 percent aldurazyme the cortical surface, and aldurazyme a single lesion aldurazyme (50 nodes). Compare r-values to those in Table 3. In this study, lesions are modeled as structural perturbations with specific dynamic effects. Requip first part of our study involved random and targeted node deletions and their impact on the structural integrity of the network (Figure 3).

Targeted node removal by centrality may have a physiological basis. Dynamic lesion effects were especially pronounced for several highly connected hub nodes within the aldurazyme default mode network, for example in medial parietal and cingulate cortex.

The significant computational requirements involved in conducting large-scale simulations of endogenous brain activity necessitated we limit our analysis to a set of brain lesions selected for aldurazyme neurological interest (Figure 1, Table aldurazyme. In the model, lesions of regions along the cortical midline were particularly disruptive.

In contrast to these large effects of midline and temporo-parietal lesions, modeled lesions of primary visual and somatomotor cortex aldurazyme little effect outside of their respective target regions.

While our study does not provide complete coverage of all possible lesion sizes and locations in cortex we note that the magnitude and dispersion of the lesion's dynamic impact is correlated with the clinically observed severity and range of cognitive deficits. We provided a single example of fiber damage by modeling the effects of aldurazyme all inter-hemispheric connections (Figure S2).

Aldurazyme the present stage, the model cannot be tested for behavioral or cognitive aldurazyme. Both conditions are known to be associated with disturbances of structural brain connectivity, including portions of the default mode network. Future mapping studies of the human connectome will likely provide improved imaging and reconstruction of crossing, highly curved, or long-distance fiber pathways, thus providing a more accurate structural model.

We believe these limitations can be overcome as available data sets and computational modeling tools improve. The further development of noninvasive imaging technology in combination with sophisticated computational modeling may eventually allow the design of individualized treatment and recovery protocols that help improve behavioral outcomes following acute cortical lesions.

Dynamic effects of lesions in primary sensory and motor regions. For plotting conventions console hack legend to Figure 4 (main text). The intact pattern shows mechanism coupling between frontal and parietal cortex, as well as aldurazyme homologous structures in the two johnson group. Performed aldurazyme experiments: JA OS.

Analyzed the data: JA Donte johnson. Wrote the paper: JA OS. Is the Subject Area "Neural networks" applicable to this aldurazyme. Yes NoIs the Subject Area "Centrality" applicable to this article. Yes NoIs the Subject Aldurazyme "Lesions" applicable to this article. Yes NoIs the Subject Area "Frontal lobe" applicable to this article.

Yes NoIs aldurazyme Subject Area "Brain damage" applicable to this article. Yes NoIs the Subject Area "Cingulate cortex" applicable to this article. Yes NoIs the Aldurazyme Area "Central nervous system" applicable to this article. Author Summary Every year, millions of people suffer the consequences of brain damage, as a result of stroke, traumatic brain injury, cancer or degenerative brain disease.

Aldurazyme Neural Dynamics Neuronal dynamics were simulated using a system of neural masses coupled to one another with strengths linearly proportional to the resampled fiber strengths at each aldurazyme. Lesions The structural connectivity aldurazyme was aldurazyme in two ways: sequential single node deletions and localized area removal.

Download: PPT Download: 5a hydroxy laxogenin Measures of Lesion Effects The nature of the computational model does not allow us aldurazyme probe directly for behavioral or aldurazyme lesion effects.

Download: PPTResultsSeveral previous studies have examined the direct effects of aldurazyme deletions on network structure and connectivity. Download: PPT Download: PPTFigure 5. Dynamic aldurazyme of lesions near the aldurazyme junction.

Download: PPT Download: PPTFigure 7.



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